{"id":882,"date":"2024-02-20T16:00:07","date_gmt":"2024-02-20T08:00:07","guid":{"rendered":"https:\/\/www.cellnuo.com\/?page_id=882"},"modified":"2024-02-20T16:00:09","modified_gmt":"2024-02-20T08:00:09","slug":"igf-1-lr3-2","status":"publish","type":"page","link":"https:\/\/www.cellnuo.com\/?page_id=882&lang=en","title":{"rendered":"IGF-1 LR3"},"content":{"rendered":"\n

Source: <\/strong>Recombinant gene engineering production, E. coli expression.<\/p>\n\n\n\n

\u4e00\u3001<\/strong>Product introduction<\/strong><\/p>\n\n\n\n

Long chain LR3 insulin-like growth factor (LR3 IGF-1), a member of the insulin gene family, is structurally similar to insulin precursor proteins and has better growth-promoting effects, which can promote the division, migration and differentiation of most cells.<\/p>\n\n\n\n

The Long chain LR3 insulin-like growth factor (LONG-R3 IGF-I) is an analogue of human IGF-I containing 83 amino acids. Compared to intact human IGF-I, there are 13 additional amino acid residues at the n-terminal. Of particular importance is that the third amino acid residue is replaced by the natural Glu with Arg (hence the name R3). Compared to natural human IGF-I, LR3 IGF-I greatly reduces its binding ability to human IGF-I binding proteins. The free concentration is higher, so the biological activity is significantly improved. In multinumber in vitro experiments, LR3 IGF-I showed good biological activity in the concentration range of 0.2-20 ng ml.<\/p>\n\n\n\n

\u4e8c\u3001Product characteristics<\/strong><\/p>\n\n\n\n

Source<\/td>Escherichia coli<\/td><\/tr>
Appearance<\/td>White, yellowish powder<\/td><\/tr>
Specific activity<\/td>Detection activity of rat L6 cell line\uff1e1.0*105U\/mg;Human cell line assay activity\uff1e6.7*105U\/mg<\/td><\/tr>
Purity (protein electrophoresis)<\/td>SDS-PAGE electrophoretic purity of up to 98%, RP-HPLC purity of up to 90%<\/td><\/tr>
Endotoxin<\/td>\uff1c0.01EU\/\u00b5g<\/td><\/tr>
Molecular weight (mass spectrum)<\/td>9112Da<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n

\u4e09\u3001<\/strong>Storage and transport stability<\/strong><\/strong><\/p>\n\n\n\n

Storage stability: Stored below -15\u2103, effective for two years.<\/p>\n\n\n\n

Transport stability: refrigerated transport, stable activity.<\/p>\n\n\n\n

\u56db\u3001<\/strong>Product advantages<\/strong><\/strong><\/p>\n\n\n\n

No animal origin: Reconstituted production, no exogenous virus pollution, the production process does not use any animal source raw materials.<\/p>\n\n\n\n

Stable quality: mass production (10+g grade production and supply), to ensure stable and continuous batch production; There is no difference between batches and the quality is stable.<\/p>\n\n\n\n

High purity: higher than life; Endotoxin and host protein residues were less than the limits of biological products.<\/p>\n\n\n\n

Freeze-dried powder: Easy to store and transport.<\/p>\n\n\n\n

Compliance with regulatory requirements: the production equipment and production environment meet the relevant regulatory requirements, and the production process fully complies with the GMP guiding principles.<\/p>\n\n\n\n

Complete quality documents: According to customer needs, relevant regulatory support documents can be provided.<\/p>\n\n\n\n

\u4e94\u3001<\/strong>Product use and suggestions<\/strong><\/strong><\/p>\n\n\n\n

When dissolved: It is recommended to dissolve with PBS, and the dissolution concentration does not exceed 1mg\/ml.<\/p>\n\n\n\n

Recommended concentration for cell culture: 5-100\u03bcg\/L.<\/p>\n\n\n\n

Recommended cell lines: HEK293, CHO cells to produce antibodies and proteins;<\/p>\n\n\n\n

Pluripotent stem cells, mesenchymal stem cells, muscle stem cells<\/p>\n\n\n\n

\u516d\u3001<\/strong>Related products<\/strong><\/strong><\/p>\n\n\n\n

Recombinant human epidermal growth factor rEGF<\/p>\n\n\n\n

Recombinant basic fibroblast growth factor bFGF<\/p>\n","protected":false},"excerpt":{"rendered":"

Source: Recombinant gene engineering production, E. col […]<\/p>\n

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